“In some cases, racemic crystallization leading to centrosymmetric space groups proved decisive in overcoming the difficulties associated with phasing.” This and more about the story behind the front cover can be found in the article !...
Thanks to Amélie Compain for this original artwork to illustrate our work on an Effective Route to 5,5,5,5’,5’,5’-Hexafluoroleucine....
Our work on hexafluoroisobutylation of enolates is now released in Chemical Science. Thanks to Amélie Compain for this beautiful and original artwork to illustrate it! ...
Our chapter entitled Urea based foldamers has just been released in the Reference work Methods in Enzymology. 50 days' free access by clicking on this link before July 24, 2021 !...
See our last paper in Science Advances showing how a foldamer backbone can adapt to recognize a specific protein surface....
Oligourea foldamers mimic peptides’ alpha-helices and effectively bind to drug targets. Our latest publication on « Structure-guided design of peptide-oligourea hybrids as inhibitors of protein-protein interactions and structural insights into protein surface recognition by oligourea foldamers» has been highlighted by the Editors of ACIE as Hot...
Our chapter entitled Foldamers in Medicinal Chemistry has just been released in the Reference work Comprehensive Supramolecular Chemistry II....
Our latest publication on molecular recognition within the cavity of a foldamer helix bundle has been published and highlighted on the cover of the Journal of the American Chemical Society. About the Cover: Towards the development of functional water-soluble foldamers, we report here the first example of self-assembled foldamers able to recognize...